Potent anti-inflammatory effects of honokiol in human fetal membranes and myometrium

YK Wijesuriya; M Lappas

Journal article

Potent anti-inflammatory effects of honokiol in human fetal membranes and myometrium

YK Wijesuriya, M Lappas

Phytomedicine | ELSEVIER GMBH | Published : 2018

DOI: 10.1016/j.phymed.2018.06.004

Abstract

Background: Preterm birth is the most prominent complication attributing to poor pregnancy and neonatal outcome. Infection is most commonly implicated in preterm birth; it initiates a cascade of inflammatory events that leads to the rupture of fetal membranes and spontaneous uterine contractions. Anti-inflammatory agents may thus be a therapeutic approach to prevent the premature rupture of fetal membranes and block contractions. In non-gestational tissues, the polyphenol honokiol has been shown to possess potent anti-inflammatory properties. Purpose: The aim of this study was to investigate the effect of honokiol on pro-inflammatory mediators in human gestational tissues. Methods: Fetal mem..

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University of Melbourne Researchers

Martha Lappas Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Associate Professor Martha Lappas is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; grant no. 1047025) and a Research Fellowship from The University of Melbourne. Funding for this study was provided by the NHMRC (grant no. 1058786), Norman Beischer Medical Research Foundation, the University of Melbourne and the Mercy Research Foundation.